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The uterine cervix plays a central role in the maintenance of pregnancy and in the process of parturition.

Freedman, “Infant and youth mortality trends by race/ethnicity and cause of death in the United States,” JAMA Pediatr.

Langhoff-Roos, “Recurrence rates after abdominal and vaginal cerclages in women with cervical insufficiency: a validated cohort study,” Arch.

Yellon, “Utility of Optical Density of Picrosirius Red Birefringence for Analysis of Cross-Linked Collagen in Remodeling of the Peripartum Cervix for Parturition,” Integr.

Mahadevan-Jansen, “Detecting biochemical changes in the rodent cervix during pregnancy using Raman spectroscopy,” Ann.

Cervical remodeling involves dramatic changes in extracellular matrix composition and, in particular, of collagen and water content during cervical ripening (a term that describes the anatomical, biochemical, and physiologic changes in preparation for labor).

Untimely cervical ripening in early gestation predisposes to preterm labor and delivery, the leading cause of infant death worldwide.

Nicolaides, “Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data,” Am.

Romero, “A soft cervix, categorized by shear-wave elastography, in women with short or with normal cervical length at 18–24 weeks is associated with a higher prevalence of spontaneous preterm delivery,” J.